Project Supervisor

Roger Geiger


I obtained my master’s and PhD degrees from ETH Zürich. During my PhD studies with Ari Helenius, I studied how non-enveloped viruses penetrate the host cell membrane. Then, I joined the laboratory of Antonio Lanzavecchia at the Institute for Research in Biomedicine (IRB) as a SystemsX postdoctoral fellow.

See more

My research focused on metabolic regulation of T cell responses. In 2016, I moved to Munich and joined the research group of Matthias Mann at the Max Planck Institute of Biochemistry. I received training in mass spectrometry-based proteomics. In 2017, I started my own research group at the IRB with the goal to study immune responses to tumors using systems biology approaches. Currently, I am Group Leader and Associate Professor at the Università della Svizzera italiana (USI).

See less


T cells are key players in the immune system with the ability to detect and eliminate infected cells and tumors. We study molecular regulations underlying T cell activation and anti-tumor activity. For this, we use a wide range of technologies including mass spectrometry-based proteomics, functional genomics, mouse models and microfluidics-based systems. Our projects aim to provide detailed insights into T cell functionality that can be translated into the clinic to improve therapies.


Canale, F., Neumann, J., von Renesse, J., Loggi, E., Pecoraro, M., Vogel, I., Zoppi, G., Antonini, G., Wolf, T., Jin, W., La Barba, G., Forkel, M., Nilsson, T., Marone, R., Mueller, H., Pelletier, N., Jeker, L., Civenni, G., Schlapbach, C., Catapano, C., Seifert, A., Gilessen, G., de Dosso, S., Cristaudi, A., Rahbari, N., Ercolani, G., Geiger, R. (2023) Proteomics of immune cells from liver tumors reveals immunotherapy targets
Cell Genomics

Canale, F., Basso, C., Antonini, G., Ning, Li., Sokolovska, A., Perotti, M., James, M., Geiger, S., Neumann, J., Jin, W., Theurillat, J.P., Leventhal, D.S., West, K., Lora, J., Sallusto, F., Geiger, R. (2021) Metabolic modulation of tumors with engineered bacteria for immunotherapy.
Nature 598(7882):662-666

Wolf, T., Jin, W., Zoppi, G., Vogel, I., Akhmedov, M., Bleck, C.K.E., Beltraminelli, T., Rieckmann, J.C., Ramirez, N.J., Notarbartolo, S., Bumann, D., Meissner, F., Grimbacher, B., Mann, M., Lanzavecchia, A., Sallusto, F., Kwee, I., Geiger, R. (2020) Dynamics in protein translation sustaining T cell preparedness
Nature Immunology 21(8):927-937

Geiger, R., Rieckmann, J., Wolf, T., Basso, C., Feng, Y., Kogadeeva, M., Picotti, P., Meissner, F., Mann, F., Sallusto, F., Zamboni, Z., Lanzavecchia, A. (2016) L-arginine modulates T cell metabolism and enhances survival and anti-tumor activity.
Cell 20;167(3):829-842