DOCTORAL
CANDIDATES
Background
In September 2021, I completed my Bachelor’s Degree in Biotechnology at the University of Barcelona, specialising in Molecular Biology. I did my thesis at the University of Stuttgart, in Germany, in Dr. Roman Fischer’s group. There, I studied the inflammatory roles of macrophages in the immune system, and how to modulate both their differentiation process and phagocytosis activity in the brain. In November 2021, after completing my studies, my profound interest in immunology and genomics led me to pursue a research stay at the Max Delbrück Center for Molecular Medicine (MDC), in Berlin, Germany, supervised by Prof. Dr. Michela di Virgilio. My work focused on the study of DNA repair systems on lymphoma cancer B cells, by successfully creating Knock-Out cell lines using the CRISPR-Cas9 genome editing tool, to study specific gene functions.
In August 2022, to broaden my expertise in genomics and computational biology, I enrolled in a two-years Master programme in Stockholm, Sweden. The programme, Molecular Techniques in Life Science, was focused on Molecular and Computational Biomedicine, and it was a joint venture between Karolinska Institute, KTH Royal Institute of Technology, and Stockholm University. There, I had the opportunity to learn about multi-omics, both at wet lab and dry lab level, specialising in spatial-omics technologies from their pioneers, the Lundeberg Spatial Lab at the Science for Life Laboratory (SciLifeLab). There, under the supervision of Prof. Dr. Patrik Ståhl, I conducted my thesis on the study and development of Spatial Transcriptomics and Spatial ATAC-sequencing, state-of-the-art techniques that allow delving into the intricacies of tissue heterogeneity and cell states, and which have revolutionised the field of genomics since its creation on the Spatial Lab.
In October 2024, to combine both my passions for immunology and genomics to a greater extent, I have joined Dr. Roser Vento-Tormo’s group, at the Wellcome Sanger Institute, to pursue a PhD at the University of Cambridge, as a Marie Skłodowska-Curie doctoral candidate within the IMMERGE programme.
Research
My current research project, part of the IMMERGE doctoral network, is conducted in the VenTo Lab, in the Wellcome Sanger Institute within the University of Cambridge. Here, my PhD is focusing on the study of the effects on hematopoietic differentiation that specific mutations have in diverse immunodeficiencies. The research is mainly focusing on the alterations affecting the JAK/STAT signalling pathway, which lead to malfunctioning of the immune system that cause autoimmunity and disproportionate inflammatory responses in patients. These mutations will be assessed both in vitro and in vivo, through genetic engineering of iPSCs and patient samples analyses, respectively. We aim to find the mutations causing these rare pathologies, screen them and validate the most promising ones on organoid models through multi-omics studies.