DOCTORAL
CANDIDATES
Background
I pursued a Bachelor’s degree in Veterinary Medicine (UAB 22’). During my Bachelor’s degree, I was involved in student representation and teaching activities (Small World Initiative), and I did 3 internships, two of which were extracurricular (at the ICU in the UAB-HCV hospital and at Prof. Dr. Francesc Jiménez’s vascular pharmacology lab). Moreover, I spend 6 months at Prof. Dr. Magnus Åbrink’s lab (SLU, Sweden), studying the role of Serglycin in the tumour microenvironment of canine mammary tumours, which allowed me to write my Bachelor's thesis. Thanks to this experience, I learnt about molecular techniques (RNA extraction, cDNA synthesis, RT-qPCR, electrophoresis) and histologic diagnosis of tumours.
After graduating, I enrolled a postgraduate programme in veterinary anatomic pathology (UAB 23’), in which I learnt to provide both macroscopic and microscopic diagnoses as well as further understanding the pathogenesis of the diseases. In parallel, I started a MSc degree in Advanced Immunology (UB-UAB 24’), which I finished after a 10 months-long internship at Prof. Dr. Sonja Buschow’s lab (EMC, Netherlands). During this internship, I learnt about tumour explant culture, ELISA and flow cytometry analysis.
Besides my academic curriculum, I have worked as a Digital Pathology intern at CRL, where I contributed to develop deep learning models to diagnose two immunology-based microscopic findings in the brain and the spleen.
Research
Effective quenching of the immune system is essential and involves several mechanism. Regulatory T cells (Tregs) are a group lymphocytes responsible to deactivate effector immune cells. Certain mutations on these lymphocytes have been associated to autoimmune conditions, in which the immune system establishes a response towards otherwise healthy self tissues. However, the exact mechanisms that regulate the function of regulatory T cells are not fully described. The aim of my work is to contribute to the understanding of how Tregs' functions are regulated. To do so, we will identify genetic mutations in these cells, and study the effect these mutations have. Then, we will study how these mutations on the genes lead to modifications on the proteins and lipids of the cell.