José Luis Sardina
I earned my Bachelor's degrees in Biology and Biochemistry from the University of Salamanca (Spain) in 2005 and 2006 respectively. I also received my Ph.D. in Biology from the same university in 2010. During my Ph.D., I researched the role of reactive oxygen species (ROS) and protein tyrosine phosphatases in hematopoietic differentiation under the supervision of Dr. Ángel Hernández Hernández and Dr. Jesús Sánchez Yagüe.
After obtaining my Ph.D., I worked as a postdoc at the Institute of Functional Biology and Genomics (IBFG, Salamanca) under the guidance of Prof. Francisco Antequera, where I researched aberrant CpG island methylation under conditions of cellular stress and cancer. In 2012, I joined the laboratory of Prof. Thomas Graf (CRG, Barcelona) for a second postdoctoral stage as a Juan de la Cierva Fellow. During this time, I focused on developing new protocols for efficient and ultrafast conversion of mouse and human pre-B lymphocytes into induced pluripotent stem cells (iPSCs). Later, I discovered the molecular mechanisms underlying cell fate conversion involving the Tet2 DNA dioxygenase in the process. In Fall 2019, I joined the Josep Carreras Leukaemia Research Institute (IJC) as a Miguel Servet researcher to lead the Epigenetic Control of Haematopoiesis group. My team is focused on understanding how aberrant DNA methylation at distal gene regulatory regions poisons the chromatin to trigger corrupted gene expression signatures in the cells, ultimately leading to disease onset and progression.